Lynch syndrome is the most common cause of hereditary cancer, significantly increasing the risk of colorectal and endometrial cancer. This condition is caused by a deficiency in the DNA mismatch repair (MMR) system. Normally, MMR proteins detect and fix errors that occur when cells duplicate their DNA. In people with Lynch syndrome, this repair mechanism does not function properly, allowing mutations to accumulate and leading to cancer development.
Traditional Lynch syndrome diagnostic methods focus on identifying mutations in MMR-related genes. However, these methods often fail to determine whether a detected mutation actually affects protein function. As a result, some cases go undiagnosed, while others receive uncertain results.
Lynsight Labs has developed DiagMMR®, an advanced test that directly assesses MMR function. Instead of searching for mutations, DiagMMR® examines whether cells can repair a reference DNA sequence with intentional mismatches. A simple skin biopsy is sent to the laboratory, where scientists analyze DNA repair activity. If repair is impaired, it indicates Lynch syndrome with high specificity and sensitivity.
Since Lynch syndrome is inherited, a positive result means family members have a 50% chance of also carrying the condition. Early diagnosis enables preventive care, helping at-risk individuals take proactive steps to reduce their cancer risk.
Learn more about Lynsight Labs and DiagMMR® at lynsightlabs.com.
