InMuneBio – INB03 / XPro1595

Our new 3D animation explains in quite a detail the mechanism of action of a novel (second-generation) TNF inhibitor – INB03, also known XPro1595.

TNF (Tumor Necrosis Factor) is an apex driver of both the “good” and “bad” aspects of immune function.

The “good” TNF (transmembrane TNF) provides various levels of support, many critical, to cells throughout the body.

The “bad” TNF, or soluble TNF causes chronic inflammation and disease.

INB03 only targets the “bad” TNF and due to this selectivity, it stops chronic inflammation and polarizes TNF activity toward its supportive functions.

This has implications in cancer, autoimmune and neurodegenerative diseases.