Chronic wound healing | Aurealis Therapeutics

Mechanism of action – 3D animation

Aurealis Therapeutics is a clinical-stage Swiss-Finnish biotech company.

Their biological drug addresses the unmet need for the treatment of chronic wounds (such as diabetic foot ulcers). Our animation shows the step-by-step mechanism of action of AUP-16.

 

THE STYLE

This is a mix of 2D and 3D styles – the elements are mostly designed in 3D, but as most of the action is happening in one place, we’ve animated the video in 2D space, which saves time and reduces production costs.

 

THE STORY

THE PROBLEM

Chronic non-healing wounds are a massive global unmet need affecting millions of patients worldwide and causing an annual cost of more than 100 billion USD. Patients suffer from pain, mobility loss, and reduced quality of life. In severe cases, chronic wounds such as Diabetic Foot Ulcers can lead to amputation and even death.

THE SOLUTION

Aurealis Therapeutics has developed AUP-16, a novel, 4-in-1 biological drug to treat chronic wounds. AUP-16 is a safe lactic acid bacterium that is genetically engineered to produce three therapeutic human proteins supporting all steps of the wound healing process. The fourth therapeutic component is the bacterium itself. 

STEP 1 – Conversion of chronic inflammation to acute inflammation 

Upon AUP-16 application, the bacteria trigger an immune response, activating resident macrophages and recruiting more immune cells to the wound site. This wake-up step re-boots the chronic inflammatory wound to an acute inflammatory wound.

STEP 2 – Converting the hostile inflammatory environment to wound healing inflammatory environment 

The proteins produced by AUP-16, in particular IL-4 and CSF-1, change the setup of the immune cells, cytokines, and growth factors, and convert the wound from a hostile pro-inflammatory state to an anti-inflammatory and regenerative state. 

STEP 3 – Proliferation 

IL4 and FGF2 induce proliferation of fibroblasts, production of extracellular matrix, growth of new blood vessels, and initiate the growth of skin epithelium. The two protein factors maintain the regenerative state for the time needed to complete wound healing. 

STEP 4 – Remodeling 

Finally, the skin epithelium regrows to close the wound and the skin layers are reinforced to form intact skin. 

 

Learn more about Aurealis Therapetuics: Aurealis Therapeutics website


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