The science
In this video for Basking Biosciences, we explain how von Willebrand factor (vWF) plays a critical role in clot formation, stabilization, and expansion. When blood vessels are damaged, vWF binds to platelets and collagen, forming a lattice that amplifies clot growth. Basking Biosciences is developing BB-31, an RNA aptamer that binds to vWF, disrupting its activity and gradually dissolving clots. By destabilizing the clot’s structure from the outer shell inward, BB-31 restores blood flow, offering a promising approach for treating acute ischemic stroke and other thrombotic conditions.
Currently in Phase 2 trials, BB-31 represents a potential breakthrough in stroke treatment and clot management.
