Thermosome

 

Thermosome: Mechanism of Action Animation

Our first fully 3D animation, showing the potential new treatment against solid tumors.

First, we explain the challenges of current treatments, which use ‘conventional’ liposomes. Then we present the solution – Thermosome’s TSLs (thermosensitive liposomes) and how combined with local hyperthermia, they can target tumors much more efficiently, and, thanks to localized action – without the risk of drug accumulation in other parts of the body.

 

THE STYLE

As the action of this video is happening mostly on a very small scale in a very limited area, it was very important to show all the nuances with a lot of detail, and that’s why the 3D style was the right choice.  Of course, the production of the video took longer than with a standard 2D explainer video, but we believe it was worth it, as the benefits and the action of the Thermosome’s TSLs are very easy to understand, even for non-experts.

 

THE STORY

Conventional liposomes are nanocarriers formed by a lipid bilayer membrane, designed to deliver drugs to tumors. They reach the tumor via the bloodstream and migrate through leaky tumor vessels.

However, only a small fraction of the liposomes reaches the tumor and only partially releases the drug, meaning it does not become fully bioavailable. At the same time, significant amounts of the liposomes are trapped in the liver and spleen. For these reasons, conventional liposomes have not achieved improved antitumor efficacy.

Thermosome’s novel thermosensitive liposomes (TSL) actively release the drug only where needed: locally in the tumor. Thermosome’s TSLs contain a novel, proprietary phospholipid called DPPG2. DPPG2 forms liposomes that are stable at body temperature, but release the drug quickly in the heated tumor area.

The patient lies in a medical device that uses image-guidance for precise local heating known as hyperthermia, which selectively heats the tumor area to about 41°C. Once the target temperature is reached, Thermosome’s TSLs are infused intravenously. TSLs instantly release the drug into the blood vessels of the heated tumor, reaching very high intravascular drug concentrations. The drug then diffuses into the surrounding tumor, achieving up to 15-fold higher local drug concentrations compared to the infusion of non-liposomal drugs. This dramatically enhances treatment efficacy.

Hyperthermia of the tumor area has additive immune-stimulating effects, similar to fever. This means that more effector T cells migrate to the tumor and heat shock proteins carrying tumor antigens are expressed, improving tumor cell recognition by the immune system.

Thermosome – Combining image-guided drug targeting with immune stimulation for improved cancer therapy.